Is Your Medication Causing Dangerous Side Effects?
There is an old saying that sometimes the cure is worse than the disease. While medications are prescribed to treat ailments, sometimes the side effects of a drug are as dangerous – or more so – than the disease itself. The Federal Food and Drug Administration has placed “black box” labels on certain drugs– warning… read more
Can Uloric Cause a Heart Attack?
Uloric (also known as febuxostat), a gout medication, has been a “hot topic” in headlines recently due to an announcement by the U.S. Food and Drug Administration (FDA) in February 2019 that a new black boxed warning was being added to its label. At issue is the discovery that Uloric carries a significant increase in… read more
Uloric vs Allopurinol: FDA says Allopurinol Should be First-Line Treatment for Gout
The FDA recently determined that Takeda Pharmaceutical’s medication, Uloric (febuxostat), should no longer be recommended as a first-line treatment for gout, a type of arthritis. After reviewing the data from a post-marketing trial required as a condition of Uloric’s approval, the FDA announced that they were requiring a new black box warning on the product… read more
Pfizer Transitions RA Patients Off 10 mg Dose After Study Shows Risk of Pulmonary Embolism
According to a recent announcement from Xeljanz manufacturer Pfizer, the company has taken steps to transition patients with rheumatoid arthritis (RA) who are taking the 10 mg twice-daily dose to the lower 5 mg twice-daily dose. The company noted that it’s taking this action based on the results of a post-marketing study that indicates significant… read more
Tenofovir and Bone Loss: What You Need to Know
One of the two key dangerous side effects at issue in pending and potential TDF lawsuits is loss of bone mineral density. Patients who have been treated with tenofovir DF-based antiretroviral HIV drugs like Atripla, Viread, and several other sister drugs, have shown an increased incidence of bone density loss and resulting conditions like osteoporosis… read more
Studies Indicate Uloric Creates Higher Risk of Mortality than Competing Gout Drugs
The FDA first approved gout medication Uloric (febuxostat) in 2009, but under one condition: the manufacturer, Takeda, had to agree to conduct a large postmarket safety clinical trial. The FDA was concerned about possible cardiovascular events with the drug and included a warning about the risk. Takeda agreed to the clinical trial, which was conducted… read more
TDF Drug Side Effects: Who Can File a Lawsuit?
At the heart of the TDF lawsuits filed against Gilead Pharmaceuticals is whether the manufacturer failed to properly warn doctors and patients of the HIV drug’s dangerous side-effects, and whether it withheld a less toxic alternative from the market in order to maximize profits. Those who took Gilead’s TDF-based HIV drugs like Viread and Truvada… read more
Study Halted When Xarelto Shown to Cause More Bleeding Than Aspirin
Researchers have stopped a study on Xarelto’s (rivaroxaban) safety and efficacy early due to “futility,” according to a press release from pharmaceutical manufacturers Bayer and Janssen Research & Development LLC. The Phase III NAVIGATE ESUS study compared Xarelto and aspirin in patients who had recently had an embolic stroke. Both medications are prescribed to help… read more
Studies Reveal New Risks Associated with Blood-Thinners Like Xarelto and Eliquis
According to a recent study published in the Journal of the American Medical Association (JAMA), blood-thinning medications like Xarelto and Eliquis may increase the risk of hematuria-related complications. Hematuria occurs when blood is found in the urine, and related complications may include emergency department visits, hospitalizations, and urologic procedures. Plaintiffs have filed thousands of lawsuits… read more
Study Suggests Some RA Patients at Increased Risk for Actemra Infections
A new study published in the scientific journal Rheumatology indicates that certain patients with rheumatoid arthritis (RA) who take Actemra (tocilizumab) to treat their symptoms may be at an increased risk for dangerous infections than others. Actemra, manufactured by Roche and subsidiary Genentech, is a drug that works by inhibiting parts of the immune system… read more