CoaguChek Recall: What You Need To Know
Warfarin sodium (Coumadin or Marevan) is the most widely used anticoagulant in the United States. This medication is vital for patients with venous thromboembolism, chronic atrial fibrillation, valvular heart disease, and mechanical prosthetic heart valves. However, due to the risk of internal hemorrhaging, monitoring is required every one to four weeks to ensure appropriate dosing…. read more
FDA Issues Black Box Warning for Uloric
In February 2019, the FDA issued a “black box warning” – the agency’s strongest and most prominent advisory — for Takeda’s popular gout drug, Uloric. According to health regulators, Uloric (febuxostat) is associated with an “increased risk of heart-related death and death from all causes” compared to the gout medication allopurinol. The boxed warning also… read more
Infection After Taking Xeljanz? Here’s What To Do!
Designed to treat rheumatoid arthritis and ulcerative colitis, Pfizer’s Xeljanz (tofacitinib) has been linked with potentially deadly side effects, which include: Liver enzyme elevations, lipid elevations, anemia, neutropenia, and lymphocyte abnormalities Increased risk of blood clots in the lungs, causing death Perforations of the stomach or intestines Lymphoma and other cancers Non-melanoma skin cancers Hypersensitivity… read more
Is Your Medication Causing Dangerous Side Effects?
There is an old saying that sometimes the cure is worse than the disease. While medications are prescribed to treat ailments, sometimes the side effects of a drug are as dangerous – or more so – than the disease itself. The Federal Food and Drug Administration has placed “black box” labels on certain drugs– warning… read more
Can Uloric Cause a Heart Attack?
Uloric (also known as febuxostat), a gout medication, has been a “hot topic” in headlines recently due to an announcement by the U.S. Food and Drug Administration (FDA) in February 2019 that a new black boxed warning was being added to its label. At issue is the discovery that Uloric carries a significant increase in… read more
Uloric vs Allopurinol: FDA says Allopurinol Should be First-Line Treatment for Gout
The FDA recently determined that Takeda Pharmaceutical’s medication, Uloric (febuxostat), should no longer be recommended as a first-line treatment for gout, a type of arthritis. After reviewing the data from a post-marketing trial required as a condition of Uloric’s approval, the FDA announced that they were requiring a new black box warning on the product… read more
Pfizer Transitions RA Patients Off 10 mg Dose After Study Shows Risk of Pulmonary Embolism
According to a recent announcement from Xeljanz manufacturer Pfizer, the company has taken steps to transition patients with rheumatoid arthritis (RA) who are taking the 10 mg twice-daily dose to the lower 5 mg twice-daily dose. The company noted that it’s taking this action based on the results of a post-marketing study that indicates significant… read more
Tenofovir and Bone Loss: What You Need to Know
One of the two key dangerous side effects at issue in pending and potential TDF lawsuits is loss of bone mineral density. Patients who have been treated with tenofovir DF-based antiretroviral HIV drugs like Atripla, Viread, and several other sister drugs, have shown an increased incidence of bone density loss and resulting conditions like osteoporosis… read more
Studies Indicate Uloric Creates Higher Risk of Mortality than Competing Gout Drugs
The FDA first approved gout medication Uloric (febuxostat) in 2009, but under one condition: the manufacturer, Takeda, had to agree to conduct a large postmarket safety clinical trial. The FDA was concerned about possible cardiovascular events with the drug and included a warning about the risk. Takeda agreed to the clinical trial, which was conducted… read more
TDF Drug Side Effects: Who Can File a Lawsuit?
At the heart of the TDF lawsuits filed against Gilead Pharmaceuticals is whether the manufacturer failed to properly warn doctors and patients of the HIV drug’s dangerous side-effects, and whether it withheld a less toxic alternative from the market in order to maximize profits. Those who took Gilead’s TDF-based HIV drugs like Viread and Truvada… read more